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演 講 人:黃俊仁博士 

演講題目: Functional Zwitterionic Silanes for Controlled Silanization and Medical Implementations 


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Organosilanes are frequently applied for surface modification of oxide surfaces to afford finely control over the physical and chemical interfacial properties. With the development of nano-materials and advances in semiconductor technologies, the precise modulation of the functional coatings using self-assemblies become of importance. This presentation will introduce current works developed in my laboratory regarding to the functional organosilanes, particularly silatranes. Silatrane possesses a tricyclic caged structure and a transannular N → Si dative bond, making it chemically stable and controllable to avoid fast hydrolysis and aggregation in solution. Silatrane allows faster deposition and better formation of thin and homogeneous films than conventional organosilanes. We have demonstrated the excellent stability and antifouling properties of zwitterionic silatranes for silicon-based substrates. Moreover, the coating technology was extended to development of a new hemofiltration system for continuously capturing of circulating tumor cells (CTCs) from a large volume of whole blood. The system was equipped a column that was packed with antifouling zwitterionized silica microspheres. The silica microspheres were modified with sulfobetaine silane (SBSi) to inhibit fouling, resist clogging, and give a high surface wettability and prolonged operation time. Packed microspheres with different diameters formed size-controllable interstitial pores that effectively captured CTCs by ligand-free size selection. A large quantity of colorectal cancer cells was spiked into sheep blood, and the sample was circulated for 5 h with a total operational volume of 2 L followed by collection and culture in vitro. The results showed that the proposed hemofiltration device selectively removed abundant CTCs from in vitro circulatory blood. The viable cells were harvested for amplification and potential applications for precision medicine.     

Ph.D magno cum laude (with great praise)    MOLECULAR BIOPHYSICS, Johannes Gutenberg Universität Mainz and Max Planck Institute for Polymer Research, Germany, 2010.
M.S.     CHEMICAL ENGINEERING, National Taiwan University, Taipei, Taiwan, 2003.
B.S.      CHEMICAL AND MATERIALS ENGINEERING, Chang Gung University, Taoyuan, Taiwan, 2001.

Jan. 2022- present Distinguished Professor, Department of Chemical & Materials Engineering, National Central University, Taiwan.
Aug. 2021- present Professor, Department of Chemical & Materials Engineering, National Central University, Taiwan.
Aug. 2020- Jul. 2021 Associate Professor, Department of Chemical & Materials Engineering, National Central University, Taiwan.
Aug. 2015-Jul. 2020 Associate Professor, Department of Biomedical Sciences & Engineering, National Central University, Taiwan.
Feb. 2012- Jul. 2015 Assistant Professor, Graduate Institute of Biomedical Engineering, National Central University, Taiwan.
Feb. 2011-Dec. 2011 Postdoctoral research associate in Shaoyi Jiang’s lab, the University of Washington, WA, USA.