3/4 Seminar Speech

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Speaker: Professor Jie-Ren Li

Topic: Functional Bio-Interfaces Fabricated via Template-Mediated Self-Assembly Processes for Investigating Cell Activations

SpeakerProfessor Jie-Ren Li

OrganizationDepartment of Chemistry, National Cheng Kung University

TopicFunctional Bio-Interfaces Fabricated via Template-Mediated Self-Assembly Processes for Investigating Cell Activations

Date10:20 , 2019.3.4

LocationRoom 203, College of Engineering

Education

Louisiana State University (USA) / Chemistry / Ph. D.

National Chiao Tung University / Applied Chemistry / MS

National Chung Cheng University / Chemistry / BS

Work Experience

National Cheng Kung University / Department of Chemistry / Assistant Professor

University of California, Davis, California, USA / Chemistry and NEAT-ORU Spectral Imaging Facility / Postdoctoral Fellow

Abstract

In nature, many cellular signaling processes begin from forming clusters on the membrane at both the micro- and nanoscale, which is a crucial prerequisite for the efficiency and regulation of cellular responses. However, even with a wealth of information regarding the specific signaling pathways, it is not clear how the geometry of the signaling clusters impacts the propagation of the signaling cascades. The main reason is a lack of technology allowing characterization of clusters as well as methodology capable of multilevel molecular positioning. Control of the relative position and orientation of nanomaterials on surfaces enables the development of well-defined molecular architectures to serve as the analytical platform for investigation of cell activation processes. A fabrication strategy based on template-mediated molecular assembly can be used to prepare multiscale bio-interfaces compatible with the natural signaling clusters. Accumulating information from using bio-interfaces might decipher various biological processes that can regulate specific cell functions at nanoscale, further leading to practical consequences for controlling cell proliferation and differentiation of specific cells.

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