3/4(一)專題演講公告

 

演講人李介仁   教授

服務單位成功大學化學系

演講題目Functional Bio-Interfaces Fabricated via Template-Mediated Self-Assembly Processes for Investigating Cell Activations

演講時間10834(星期一)早上1020

演講地點工綜館203國際演講廳

個人學歷

路易斯安那州立大學 / 化學博士

國立交通大學 / 應用化學碩士

國立中正大學 / 化學學士

個人經歷

國立成功大學 / 化學系 / 助理教授(現職)

美國加州大學戴維斯分校 / Chemistry and NEAT-ORU Spectral Imaging Facility / 博士後研究員

演講摘要

In nature, many cellular signaling processes begin from forming clusters on the membrane at both the micro- and nanoscale, which is a crucial prerequisite for the efficiency and regulation of cellular responses. However, even with a wealth of information regarding the specific signaling pathways, it is not clear how the geometry of the signaling clusters impacts the propagation of the signaling cascades. The main reason is a lack of technology allowing characterization of clusters as well as methodology capable of multilevel molecular positioning. Control of the relative position and orientation of nanomaterials on surfaces enables the development of well-defined molecular architectures to serve as the analytical platform for investigation of cell activation processes. A fabrication strategy based on template-mediated molecular assembly can be used to prepare multiscale bio-interfaces compatible with the natural signaling clusters. Accumulating information from using bio-interfaces might decipher various biological processes that can regulate specific cell functions at nanoscale, further leading to practical consequences for controlling cell proliferation and differentiation of specific cells.

20190304