5/28(一)專題演講公告

 20180528

演講人黃郁棻 教授

服務單位國立清華大學生醫工程與環境科學系

演講題目Anisotropic Gold-based Nanoplatform for Anticancer Therapy

演講時間107年5月28日(星期一)早上10點20分

演講地點工綜館203國際演講廳

個人學歷

國立臺灣大學 / 化學系 / 博士

國立臺灣大學 / 化學系 / 學士

個人經歷

國立清華大學生醫工程與環境科學系 / 副教授(現職)

國立清華大學生醫工程與環境科學系 / 助理教授

美國佛羅里達大學化學系 / 博士後研究

國立臺灣大學化學系 / 研究助理

 演講摘要

Chemotherapy is an important modality in cancer treatment. The major challenges in this research field are to improve drug loading, increase selectivity to target cells, and control the precise release of drugs. In the past few years, various aptamer-gold nanoconjugates have been developed by our groups as innovative carriers for targeted and controlled drug delivery. Multifunctional surface modification allows an enhanced recognition and uptake of drug carriers by targeted cells. With the strong photothermal responsiveness of anisotropic gold nanoparticulate, the release of drugs could be facilitated in a controlled manner upon near-infrared light irradiation. The synergistic effect resulting from the combination of chemotherapy and photothermal therapy permits high therapeutic efficacy for drug-resistant cancer cell killing. On the other hand, a novel delivery system was also designed by cross-linking of serum albumin on the surface of gold nanorods to achieve high drug loading efficiency. The as-prepared core-shell nanostructures exhibit excellent compatibility in various biological environments, tremendous drug loading capacity and greater photoacoustic signal generation efficiency than pristine gold nanorods. It performs a strong contrast enhancement for photoacoustic imaging of tumors. The therapeutic efficacy of drug-loaded nanocarriers against Tramp-C1 prostate cancer was further improved both in vitro and in vivo when subjected to additional near-infrared photothermal heating. Our finding suggests this developed core-shell nanoplatform is highly promising for in vivo theranostic applications. Additionally, the resulting drug nanocarrier was also designed for effective macrophage-mediated delivery to demonstrate how nanoparticle-loaded macrophages improve chemodrug distribution and retention ability to achieve enhanced antitumor effects. The serum albumin shell of these nanoagents served as a drug reservoir to delay the intracellular drug release and drug-related toxicity that impairs the host cell carriers. Near-infrared laser irradiation enabled on-demand payload release to destroy neighboring tumor cells. In comparison with pristine nanoparticles or free drug, the nanoengineered macrophages effectively demonstrate the importance and effect of homogeneous drug distribution and retention ability in cancer therapy.

20180528